cemadotin free base

Research use only, not for human use.

Cemadotin free base(LU103793 free base) is a novel anti-limiting peptide , an analog of Dolastatin 15, a naturally occurring cytotoxic peptide that blocks mitosis and inhibits microtubules (tubulin) with a Ki of 1 μM. Cemadotin is used in research against cancer.

Cemadotin (LU103793) is an analogue of Dolastatin 15 (HY-P1126) which is naturally occurring cytotoxic peptides. Cemadotin blocks cells at mitosis, and exhibits Ki value of 1 μM for inhibiting tubulin. Cemadotin can be used to research anticancer.

Cemadotin (0-100 μM; 35 min) inhibits polymerization dose-dependently in Tubulin-treated Strongylocentrotus purpuratus.Cemadotin (0-1000 nM) preferentially suppresses the rate and extent of growing excursions of tubulin, and suppression is dependent upon the drug concentration.Cemadotin (0-1 μM) markedly increases the rescue frequency but had little effect on the catastrophe frequency.Cemadotin (400 pM~300 nM; 72 h) inhibits cancer cells HEK 293, F9 and HL60.Cell Proliferation Assay Cell Line:HEK 293, F9 and HL60 Concentration:400 pM~300 nM Incubation Time:72 h Result:Exhibited cytotoxicity against HEK 293, F9 and HL60 with IC50s of 0.7 nM, 14.8 nM and 0.5 nM, respectively.

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Others

Other Targets

Microtubule Associated

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159776-69-9

640.86

C35H56N6O5

>98% (HPLC)

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C([C@@H](N(C([C@@H](NC([C@H](C(C)C)N(C)C)=O)C(C)C)=O)C)[C@@H](C)C)(=O)N1[C@H](C(=O)N2[C@H](C(NCC3=CC=CC=C3)=O)CCC2)CCC1

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(-20℃)

With Ice Pack

≥ 2 years